Fig. 3.

Normal reconsolidation of contextual fear memory in younger 5XFAD mice. Experimental design used is presented at the top of each panel. (A) 5XFAD mice at 3–4 months of age and their wild-type littermate mice were trained with 2 CS/US pairings for contextual fear conditioning. Mice received a single 3-min re-exposure to the conditioning context 24 h after training, and were then tested for contextual memory 24 h later (n = 9–12 mice per group). (B) 5XFAD mice at 6–7 months of age and their wild-type littermate mice were similarly tested for reconsolidation except that they were trained with 5 CS/US pairings (n = 9–10 mice per group). In either case, levels of freezing were not significantly different between 5XFAD (closed columns) and wild-type mice (open columns) or between the re-exposure and subsequent memory test sessions. However, a trend toward a decrease in reconsolidation was observed in 5XFAD mice at 6–7 months of age as compared to wild-type littermate controls during memory testing 24 h after re-exposure (p = 0.11). All data are presented as mean ± SEM.