Figure 2.

Expression dynamics of up- and down-regulated glycogenes during the onset of mouse C2C12 differentiation. (A) According to their expression profiles, the 37 glycogenes expressed with more than-4 fold variations were analyzed using a principal component analysis (PCA). Gene expression profiles in differentiated C2C12 cells were plotted according to the plan defined by the two first principal components, PC1 and PC2. The PC1 axis corresponds to the gradient of gene expression occurring in the time course. Each vector, numbered 0 to 72 h, represents the orientation for genes increasing along each time. In the opposite direction to these vectors are genes whose expression decreased. (B) A dendrogram representation of the hierarchical cluster analysis of the 37 gene expression levels shows three distinct clusters. (C) Expression dynamics of glycogenes were modeled according to their membership cluster.