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The top five ranking pharmacophore hypotheses generated using PHASE.a
| Pharmacophore | Pharm_A | Pharm_B | Pharm_C | Pharm_D | Pharm_E |
|---|---|---|---|---|---|
| Ranking | 1 | 2 | 3 | 4 | 5 |
| Features | AAAHRR | AAAHRR | AADHRR | AAAHRRR | AADHRR |
| Conformation of aligned molecules | anti | anti | anti | anti | anti |
The features defined in PHASE include: hydrogen bond acceptor (A), hydrogen bond donor (D), hydrophobic group (H), negatively charged group (N), positively charged group (P), and aromatic ring (R).
