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Experimental design
| Time (weeks) | Assessment | Experimental groups | |||
|---|---|---|---|---|---|
| Nondiabetic | Diabetic | ||||
| Sham surgery* | Sham surgery* | 0 μg OP-1 + carrier | 25 μg OP-1 + carrier | ||
| 2 | Radiographic histologic | 5 | 5 | 6 | 4 |
| 4 | Radiographic histologic | 6 | 6 | 4 | 6 |
| Biomechanical | 6 | 4 | 6 | 5 | |
* Control animals in which closed fracture was created and fracture site was opened and then closed without treatment; OP-1 = osteogenic protein-1.
