Table 2.

Serum glucose levels during the study period

Time (days)	Experimental groups
	Nondiabetic	Diabetic
	Sham surgery*	Sham surgery*	0 μg OP-1 + carrier	25 μg OP-1 + carrier
Prestreptozotocin injection, Day 0	130 ± 3	133 ± 3	132 ± 6	133 ± 5
Fracture creation, treatment, Day 14	209 ± 29	384 ± 15†	402 ± 18†	414 ± 12†
2 weeks postoperatively, Day 28	213 ± 49	334 ± 13†	372 ± 27†	385 ± 21†
4 weeks postoperatively, Day 42	208 ± 24	388 ± 24†	440 ± 16†	400 ± 19†

Serum glucose levels in mg/dL are given as mean and standard error of the mean; *control animals in which closed fracture was created and fracture site was opened and then closed without treatment; ^†greater than prestreptozotocin injection levels (p < 0.001); OP-1 = osteogenic protein-1.