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Diagram of the MUTYH protein in scale; known functional domains (the filled boxes) data derived from Sampson et al, 2005 [43]; and three types of well known typical mutations - missense or in-frame, splice and truncation. APE1, apurinic endonuclease 1; HhH, helix-hairpin-helix; PCNA, proliferating-cell nuclear antigen; RPA, replication protein A.
