Table 1. Gene ontology groups with significant over-representation among genes with ≥2-fold increased expression in diabetic.

GO Classification	Specific GO Term	Number of Genes	P Value
Biological Process	Protein Ubiquitination	4	0.0053
	Morphogenesis	10	0.012
	Bone Mineralization	3	0.012
	Bone Remodelling	3	0.035
	Organogenesis	8	0.047
	Skeletal Development	3	0.048
	Organ Development	8	0.048
Molecular Function	Catalytic Activity	30	0.000034
	Ligase Activity, Forming Carbon-Nitrogen Bonds	5	0.001
	Ubiquitin-Protein Ligase Actvitity	4	0.0038
	Ligase Actvitity	5	0.0054
	Oxidoreductase Activity	8	0.024
	Palmitoyl-CoA Hydrolase Activity	2	0.037
Cellular Constituent	Ubiquitin Ligase Complex	4	0.0033
	Intracellular	23	0.017

P values reflect statistical significance of each GO term being over-represented among genes with increased expression.