Table 3. Gene ontology groups with significant over-representation among genes with ≥2-fold reduced expression in diabetic.

GO Classification	Specific GO Term	Number of Genes	P Value
Biological Process	Carbohydrate Metabolism	8	0.000061
	Alcohol Metabolism	6	0.0077
	Glucose Metabolism	5	0.0036
	Alcohol Catabolism	4	0.0038
	Cellular Carbohydrate Catabolism	4	0.0042
	Cellular Carbohydrate Metabolism	5	0.005
	Hexose Metabolism	5	0.0059
	Monosaccharide Metabolism	5	0.0059
	Glucose Catabolism	4	0.011
	Hexose Catabolism	4	0.011
	Monosaccharide Catabolism	4	0.011
	Glycolysis	4	0.02
	Organogenesis	7	0.032
	Organ Development	7	0.033
	Generation of Precursor Metabolites and Energy	6	0.048
Molecular Function	Extracellular Matrix Structural Constituent	5	0.00001
	Calcium Ion Binding	10	0.00003
	Ion Binding	12	0.0013
	Metal Ion Binding	12	0.0013
	Cation Binding	10	0.0072
Cellular Constituent	Collagen	4	0.00014
	Extracellular Region	13	0.00032
	Fibrillar Collagen	3	0.00033
	Extracellular Matrix (Sensu Metazoa)	6	0.0026
	Extracellular Matrix	6	0.0027
	Extracellular Space	8	0.011
	Collagen Type V	2	0.018
	Organelle Lumen	2	0.046

P values reflect statistical significance of each GO term being over-represented.