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. 2009 Nov 17;4(11):e7789. doi: 10.1371/journal.pone.0007789

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Shen et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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a) Antigenic structure of A/PR/8/34 (H1N1) HA (PDB accession code 1RU7 [78]). Five antigenic sites were identified by using a large number of monoclonal antibodies [73], [74]: Sa (cyan), Sb (red), Ca1 (yellow), Ca2 (green), Cb (blue), using H3 HA numbering. The receptor-binding site (RBS) was labeled for reference. b) Codons on A(H1N1) HA that were identified to be under various selection in PAML and HyPhy analysis.