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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: Bioconjug Chem. 2009 Sep;20(9):1799–1806. doi: 10.1021/bc900243r

Table 1.

Summary of properties of the screened dendrimers concerning in vitro parameters 162×88mm (300 × 300 DPI)

Generation-1 rigid Generation-2 rigid Generation-3 rigid Generation-2 flexible Generation-2 bow-tie
Primary amines 6 12 24 12 16
Amine density [Da/N atom] 211.27 245.30 262.20 262.32 262.20
DNA condensation at plateau [%] 48.0 30.2 4.2 36.4 5.9
Size [nm] 338.3 154.8 230.2 426.3 882.0
Zeta potential [mV] −0.05 22.6 17.7 −7.5 3.1
Hemolysis [%] 12.6 10.9 12.9 6.11 13.0
Toxicity (IC50) [μg/ml] 501.2 64.3 20.1 22.8 115.3
Transfection efficiency (N/P 5, MeWo) [RLU/s] 2480.0 4948.3 7087.3 44184.0 4487.0