. Author manuscript; available in PMC: 2010 Sep 1.

Published in final edited form as: Bioconjug Chem. 2009 Sep;20(9):1799–1806. doi: 10.1021/bc900243r

Table 1.

Summary of properties of the screened dendrimers concerning in vitro parameters 162×88mm (300 × 300 DPI)

	Generation-1 rigid	Generation-2 rigid	Generation-3 rigid	Generation-2 flexible	Generation-2 bow-tie
Primary amines	6	12	24	12	16
Amine density [Da/N atom]	211.27	245.30	262.20	262.32	262.20
DNA condensation at plateau [%]	48.0	30.2	4.2	36.4	5.9
Size [nm]	338.3	154.8	230.2	426.3	882.0
Zeta potential [mV]	−0.05	22.6	17.7	−7.5	3.1
Hemolysis [%]	12.6	10.9	12.9	6.11	13.0
Toxicity (IC50) [μg/ml]	501.2	64.3	20.1	22.8	115.3
Transfection efficiency (N/P 5, MeWo) [RLU/s]	2480.0	4948.3	7087.3	44184.0	4487.0