Fig. 2.

Temporal and dosage effects of Wnt1 activation during early development. Dorsal views of Wnt1-transgenic embryos. a The heat shock was performed at different stages for 2 h at 39°C. b Wnt1-transgenic embryos were heat-shocked at early gastrulation for different durations. The Gfp activity 1 day after heat shock was used as a marker. Ectopic otic vesicles are indicated by arrows. n the number of examined embryos, ep. epiboly, ey eye, fb forebrain, md midbrain, hb hindbrain, ov otic vesicle