Table 4.
Coordinates of Regional Differences in Gray Matter Volume in Subjects with Fragile X (n = 62) Compared with Typically Developing Control Subjects (n = 63)
| All Subjects Combined Regressing Out Site |
Stanford Z-score |
Hopkins Z-score |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cluster Size |
Z- score |
p | Peak MNI Coordinates (x, y, z) |
Peak TAL Coordinates (x, y, z) |
|||||||
| Clusters of higher gray matter volume in FraX versus control | |||||||||||
| Left caudate head | 9,855 | 6.75 | <0.001 | -10 | 26 | 5 | -10 | 25 | 3 | 4.65 | 4.75 |
| Right caudate head | 6.72 | 9 | 26 | 6 | 9 | 25 | 4 | 4.55 | 4.88 | ||
| Right fusiform gyrus (BA 37) |
612 | 5.23 | 0.01 | 48 | -50 | -17 | 48 | -49 | -12 | 3.54 | 3.79 |
| Clusters of lower gray matter volume in FraX versus control | |||||||||||
| Left orbital frontal cortex | 25 | 4.91 | 0.01 | -30 | 46 | -21 | -30 | 44 | -20 | 3.09 | 4.94 |
| Left superior temporal gyrus (BA 39) |
28 | 4.71 | 0.03 | -44 | -59 | 18 | -44 | -56 | 19 | 4.18 | 2.6 |
MNI = Montreal Neurological Institute; TAL = Talairach.