Scheme 1. Chemistry of the FAPY Adduct Following Base-Catalyzed Ring-Opening of the AFB-N7-dGuo Cationic Adduct.
The adduct interconverts between AFB-α-FAPY and AFB-β-FAPY anomers; the equilibrium is dependent on single strand vs duplex DNA environments.(32) Geometrical isomers of the formamide group and atropisomers about the C5−N5 bond are also observed.(32)