Table 3.
Adjusted mean changes [95% confidence intervals] † in FVC, FEV1, and FEV1 to FVC ratio over 3 years of follow-up by diabetes status at baseline.
| ΔFVC (ml/yr) | ΔFEV1 (ml/yr) | ΔFVC %pred (%/yr) | ΔFEV1 %pred (%/yr) | ΔFEV1/FVC (%/yr) | |
|---|---|---|---|---|---|
| No Diabetes | ↓ 58 [56 – 59] | ↓ 47 [45 – 48] | ↓ 0.96 [0.9 – 1.0] | ↓ 0.7 [0.7 – 0.8] | ↓ 0.1 [0.07 − 0.1] |
| Diabetes | ↓ 64 [59 – 69] | ↓ 49 [46 – 53] | ↓ 1.1 [1.0 – 1.3] | ↓ 0.9 [0.7 – 1.0] | ↓ 0.05 [−0.02 − 0.1] |
| P value | 0.01 | 0.13 | 0.009 | 0.08 | 0.22 |
| Diabetes by fasting glucose (mg/dL) | |||||
| < 140 | ↓ 63 [53 – 72] | ↓ 49 [42 – 56] | ↓ 1.1 [0.8 – 1.3] | ↓ 0.8 [0.6 – 1.0] | ↓ 0.1 [−0.03 – 0.2] |
| 140 – 199 | ↓ 61 [52 – 69] | ↓ 47 [40 – 53] | ↓ 1.1 [0.9 – 1.3] | ↓ 0.8 [0.6 – 1.0] | ↓ 0.1 [−0.1 – 0.2] |
| 200+ | ↓ 56 [46 – 65] | ↓ 47 [40 – 54] | ↓ 0.9 [0.7 – 1.2] | ↓ 0.8 [0.5 –1.0] | ↓ 0.2 [0.01 – 0.3] |
| P for trend‡ | 0.59 | 0.89 | 0.65 | 0.88 | 0.83 |
| Diabetes by duration (years) | |||||
| <=5 | ↓ 57 [48 – 67] | ↓ 45 [38 – 52] | ↓ 1.0 [0.7 – 1.3] | ↓ 0.7 [0.5 – 1.0] | ↓ 0.1 [−0.1 – 0.1] |
| 6 – 9 | ↓ 63 [47 – 79] | ↓ 52 [40 – 63] | ↓ 1.1 [0.7 – 1.5] | ↓ 0.9 [0.5 – 1.3] | ↓ 0.1 [−0.3 – 0.1] |
| >=10 | ↓ 68 [57 – 79] | ↓ 50 [41 – 58] | ↓ 1.3 [1.0 – 1.6] | ↓ 0.9 [0.6 – 1.2] | ↑ 0.03 [−0.1 – 0.2] |
| Unknown | ↓ 65 [59 – 72] | ↓ 51 [46 – 56] | ↓ 1.2 [1.0 – 1.3] | ↓ 0.9 [0.7 – 1.1] | ↓ 0.1 [−0.2 – 0.0] |
| P for trend in known duration‡ | 0.07 | 0.42 | 0.05 | 0.31 | 0.11 |
| Diabetes by medications | |||||
| No medication | ↓ 63 [57 – 69] | ↓ 48 [44 – 53] | ↓ 1.1 [0.9 – 1.3] | ↓ 0.8 [0.7 – 1.0] | ↓ 0.1 [−0.02 – 0.1] |
| Oral agents | ↓ 57 [48 – 66] | ↓ 50 [43 – 57] | ↓ 1.0 [0.7 – 1.2] | ↓ 0.9 [0.6 – 1.1] | ↓ 0.2 [0.1 – 0.3] |
| Insulin (alone or with oral) | ↓ 79 [68 – 90] | ↓ 52 [44 – 61] | ↓ 1.5 [1.2 – 1.9] | ↓ 0.9 [0.6 – 1.2] | ↑0.2 [−0.4 −0.1] |
| P for trend‡ | 0.001 | 0.40 | 0.001 | 0.33 | 0.0003 |
†
Adjusted for baseline age, gender, race, height, BMI, waist circumference, pack-years of smoking, sport activity index, education level, baseline lung function, BMI change from baseline to year 3, waist change from baseline to year 3, incident asthma or chronic lung disease or use of medications for the conditions at 3-year follow-up, and ARIC center.
‡
P values correspond to tests for linear trend across categories.