Table 2.
Administered Therapy
| Treatment | Cohort 1 (n = 27) | All Patients (N = 71) |
|---|---|---|
| Total No. of cycles | 293 | 538 |
| Cycles per patient, No. of cycles | ||
| Median | 5 | 4 |
| Range | 1-72 | 1-72 |
| Cycles per patient, No. of patients | ||
| ≤ 2 | 4 | 13 |
| 3-5 | 10 | 31 |
| ≥ 6 | 13 | 27 |
| No. of doses per patient | ||
| Median | 15 | 12 |
| Range | 2-141 | 2-141 |
| No. of doses | ||
| Total | 756 | 1,462 |
| Full dose | 554 | 1,110 |
| Dose escalated | 39 | 102 |
| Reduced, total | 163 | 250 |
| Reduced as a result of toxicity | 22 | 42 |
| Held* | 2 | 8 |
| Dose administered | ||
| Cumulative dose, mg/m2 | ||
| Median | 210 | 168 |
| Range | 28-2,538 | 28-2,538 |
| Cumulative dose, mg | ||
| Median | 386 | 306 |
| Range | 43-5,681 | 43-5,681 |
*
According to protocol criteria.