Table 4.
Drug-Related Cycle 1 Toxicities
| Toxicity | % of Patients |
|||
|---|---|---|---|---|
| Grade 1 | Grade 2 | Grade 3 | Grade 4 | |
| Hematologic | ||||
| Leukopenia | 4 | 14 | 11 | 1 |
| Granulocytopenia | 8 | 14 | 10 | 4 |
| Lymphopenia | 21 | |||
| Thrombocytopenia | 27 | 7 | 6 | |
| Anemia | 20 | 11 | 6 | |
| Constitutional/GI | ||||
| Fatigue | 27 | 7 | 6 | 1 |
| Headache | 4 | 3 | ||
| Nausea | 34 | 15 | 3 | |
| Vomiting | 11 | 7 | 1 | |
| Anorexia | 13 | 7 | 1 | |
| Dysgeusia | 18 | 1 | ||
| Constipation | 3 | 4 | ||
| Diarrhea | 7 | 1 | ||
| ECG | ||||
| T-wave or ST changes | 71 | 9 | ||
| QTc prolongation | 9 | |||
| Cardiac | ||||
| Hypotension | 3 | |||
| Supraventricular arrhythmia | 1 | 1 | ||
| Ventricular arrhythmia | 3 | |||
| Laboratory | ||||
| Hypoalbuminemia | 14 | 6 | ||
| Hyperbilirubinemia | 3 | |||
| AST | 8 | 1 | 3 | |
| ALT | 4 | 1 | 3 | |
| Hyperglycemia | 11 | 7 | ||
| Hypermagnesemia | 7 | |||
| Hyperuricemia | 11 | 4 | ||
| Hypocalcemia | 10 | 31 | 1 | |
| Hypoglycemia | 4 | 1 | ||
| Hypokalemia | 8 | 1 | ||
| Hypomagnesemia | 15 | |||
| Hyponatremia | 8 | |||
| Hypophosphatemia | 1 | 3 | 4 | |
NOTE. Drug related was defined as possibly, probably, or definitely related to the drug.