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. Author manuscript; available in PMC: 2010 May 1.
Published in final edited form as: Nat Cell Biol. 2009 Oct 18;11(11):1287–1296. doi: 10.1038/ncb1973

Figure 3. Nuclear accumulation of Smad2 in singly-moving cells.

Figure 3

A: Low magnification image of a primary MTLn3E tumour expressing GFP-Smad2 and NLS-Orange. B: Time series of higher magnification images of GFP-Smad2 and NLS-Orange expressing primary tumours are shown. i), ii) and iii) show areas including singly-moving (see also Movie 6), cohesively moving (see also Movie 7), and stationary cells (see also Movie 8), respectively. C: Quantification of Smad2 localisation in non-motile, singly-moving, and collectively moving cells in primary tumours, lymph node and lung metastases. 26 movies from 6 mice were analysed D: GFP-Smad2 localisation in a lymph node metastasis and different size lung metastases.