Table 1.
Mean and median plasma one-carbon metabolite levels in the NHS CGEMS, SHARe Women and SHARe Men study populations with GW data
| NHS CGEMSa, n = 1,658 | SHARe Women, Exam 6b, n = 1,647 | SHARe Men, Exam 6b, n = 1,458 | |
|---|---|---|---|
| Age, Mean, SD | 58.92, 6.20 | 58.60,9.71 | 58.57, 9.70 |
| Plasma HCYc, Mean, SD | 11.52, 5.41 | 9.06, 3.87 | 10.54, 3.99 |
| Plasma HCY Median (IQRd) | 10.62 (4.04) | 8.39 (3.32) | 9.82 (3.55) |
| Plasma Folatee, Mean, SD | 10.02, 9.03 | 7.85, 5.32 | 6.54, 4.23 |
| Plasma Folate Median (IQRd) | 7.69. (7.44) | 6.45 (5.80) | 5.68 (4.22) |
| Plasma B12f, Mean, SD | 473.90, 249.53 | 435.10, 181.80 | 398.59, 148.26 |
| Plasma B12 median (IQRd) | 436.31 (224.0) | 405.96 (211.91) | 377.34 (172.68) |
| Plasma PLPg, Mean, SD | 76.39, 90.55 | 83.14, 82.76 | 86.89, 84.05 |
| Plasma PLP median (IQRd) | 46.70 (47.77) | 57.55 (56.87) | 61.72 (52.61) |
aNHS blood collection was during 1989–1990.
bExam 6 refers to Framingham Heart Study laboratory exam 6 measurements (1995–1998). For all plasma, one-carbon metabolites exam 6 measurements were used in this analysis because this exam had the largest sample size, and laboratory measurements were conducted using assays comparable to NHS CGEMS.
cPlasma HCY measured in μmol/l; data were log-transformed for GWAS analysis.
dIQR, interquartile range.
ePlasma Folate measure in ng/ml; data were log-transformed for GWAS analysis.
fPlasma Vitamin B12 measured in pg/ml; data were log-transformed for GWAS analysis.
gPlasma PLP measured in pmol/ml; data were log-transformed for GWAS analysis.