Table 1.
Run-in medication, treatment combination after adding brinzolamide, baseline characteristics, time point(s) of intraocular pressure measurements and absolute (mmHg) and relative (%) decrease from baseline intraocular pressure for peak and trough time points
| Trial | Run-in medication | Treatment combination after run-in | No. of patients baseline (% withdrawals) | Sex (M/F) | Mean age (y) | POAG (%) | OHT (%) | Endpoint of measurement (months) | Baseline IOP (mmHg) mean ± SD | Time point(s) of IOP measurements | IOP decrease (mmHg) mean ± SD | IOP decrease (%) mean ± SD |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Trough | ||||||||||||
| Shin 200054 | 0.5% timolol bid | 0.5% timolol bid and 1% brinzolamide tid | 53 (11.3) | 28/25 | 61 | 59 | 41 | 1 | 25.5 ± nr | +0 timolol +0 brinzolamide |
–3.3 ± nr | –13.2 ± nr |
| Michaud et al 200155 | 0.5% timolol bid | 0.5% timolol bid and 1% brinzolamide tid | 104 (6.7) | 54/50 | nr | 57 | 37 | 1 | 25.5 ± 1.9 | +0 timolol +0 brinzolamide |
–3.6 ± 3.0 | –14.1 ± 11.4 |
| Martinez et al 200956 | 0.5% timolol bid | 0.5% timolol bid and 1% brinzolamide tid | 76 (54) | 41/35 | 64 | 100 | 0 | 60 | 22.7 ± 1.2 | nr | –4.3 ± nr | –18.9 ± nr |
| Kaback et al 200857 | washout | 0.5% timolol/1% brinzolamide bid (fixed) | 171 (7.5) | 80/91 | nr | 63 | 37 | 3 | 27.1 ± 2.7 | +0 timolol +0 brinzolamide |
–8.3 ± 3.8 | –30.6 ± 13.6 |
| Manni et al 200958 | washout | 0.5% timolol/1% brinzolamide bid (fixed) | 220 (7.3) | 96/124 | 65 | 78 | 22 | 3 | 27.3 ± nr | +0 timolol +0 brinzolamide |
–9.1 ± nr | –33.3 ± nr |
| Peak | ||||||||||||
| Shin 200054 | 0.5% timolol bid | 0.5% timolol bid and 1% brinzolamide tid | 53 (11.3) | 28/25 | 61 | 59 | 41 | 1 | 25.5 ± nr | +0 timolol +0 brinzolamide |
–3.3 ± nr | –14.3 ± nr |
| Michaud et al 200155 | 0.5% timolol bid | 0.5% timolol bid and 1% brinzolamide tid | 104 (6.7) | 54/50 | nr | 57 | 37 | 1 | 25.5 ± 1.9 | +0 timolol +0 brinzolamide |
–4.9 ± 2.6 | –20.3 ± 10.5 |
| Martinez et al 200956 | 0.5% timolol bid | 0.5% timolol bid and 1% brinzolamide tid | 76 (54) | 41/35 | 64 | 100 | 0 | 60 | 22.7 ± 1.2 | nr | –4.3 ± nr | –18.9 ± nr |
| Kaback et al 200857 | washout | 0.5% timolol/1% brinzolamide bid (fixed) | 171 (7.5) | 80/91 | nr | 63 | 37 | 3 | 25.8 ± 3.0 | +0 timolol +0 brinzolamide |
–8.7 ± 3.9 | –33.7 ± 14.7 |
| Manni et al 200958 | washout | 0.5% timolol/1% brinzolamide bid (fixed) | 220 (7.3) | 96/124 | 65 | 78 | 22 | 3 | 25.9 ± nr | +0 timolol +0 brinzolamide |
–9.1 ± nr | –34.9 ± nr |
Abbreviations: M, male; F, female; Y, year; POAG, primary open-angle glaucoma; OHT, ocular hypertension; IOP, intraocular pressure; SD, standard deviation; bid, twice daily; tid, thrice daily; nr, not reported.