. 1998 May 26;95(11):6388–6393. doi: 10.1073/pnas.95.11.6388

Table 1.

Turnover of CD4⁺ and CD8⁺ T lymphocytes in normal and SIV-infected macaques

Animal	CD4⁺^*, per mm³	Viral load^*, 10³ per ml	Labeling rate, d⁻¹^†		Elimination rate, d⁻¹^‡
Animal	CD4⁺^*, per mm³	Viral load^*, 10³ per ml	CD4⁺	CD8⁺	CD4⁺	CD8⁺
Normal
246-94	1150	n/a	0.008	0.010	0.034	0.018
247-94	1500	n/a	0.008	0.006	0.020	0.012
394-95	2120	n/a	0.007 ± 0.001	0.008 ± 0.002	0.038 ± 0.006	0.021 ± 0.007
361-95	1865	n/a	0.004 ± 0.002	0.007 ± 0.001	0.033 ± 0.006	0.022 ± 0.004
Mean ± SD			0.006 ± 0.002	0.008 ± 0.002	0.033 ± 0.008	0.019 ± 0.005
SIV-infected
23-96	295	1081	0.012 ± 0.001	0.020 ± 0.005	0.096 ± 0.023	0.076 ± 0.044
105-91	507	83	0.012 ± 0.003	0.012 ± 0.003	0.083 ± 0.010	0.071 ± 0.038
168-94	846	697	0.011	0.015	0.076	0.042
196-94	861	179	0.012	0.017	0.055	0.043
377-90	337	12	0.011 ± 0.004	0.010 ± 0.006	0.116 ± 0.049	0.067 ± 0
Mean ± SD			0.012 ± 0.002^§	0.014 ± 0.006^¶	0.090 ± 0.029^§	0.064 ± 0.026^§

CD4⁺ T cell counts and viral loads represent the average of all determinations during labeling and decay phases. Values for most animals represent the mean ± SD of two independent experiments.

^†

The rate of accumulation of BrdUrd-labeled cells was determined by weighted linear regression. The mean correlation coefficient (R value) for curve fitting was 0.91.

^‡

The elimination rate of BrdUrd-labeled cells was calculated by nonlinear regression using weighted least squares analysis. The mean correlation coefficient (R value) for curve fitting was 0.86.

^§

The difference between normal and SIV-infected animals is statistically significant (P < 0.002, Mann–Whitney U test).

^¶

The difference between normal and SIV-infected animals is statistically significant (P < 0.02, Mann–Whitney U test). n/a, not applicable.