Figure 3. Lysosomal clusters of double-stranded DNA are absent in muscles of pol γ mutant larvae.

Immunolabeling of late endosomal/lysosomal compartments with anti-spin antibody (red) reveals the presence of extra-nuclear dsDNA clusters (green) in these compartments in control muscle cells (arrowheads), presumably from mitochondria undergoing mitophagy. These dsDNA clusters are absent in the lysosomes of tam ³/tam ⁹ mutant muscles. Scale bar equals 10 µm.