Figure 8. Mutations in pol γ increase mitochondrial flux in both directions but decrease only anterograde velocity.

(A) Bidirectional mitochondrial flux is increased significantly in segmental nerves of heterozygous tam³ and heteroallelic combination of pol γ ^β1/β2 and tam ³/tam ⁹; numbers at the base of columns indicate number of nerves assayed. (B) There is no significant change in the density of docked mitochondria in tam ³/tam ⁹ mutants; numbers at the base of columns indicate number of nerves assayed. (C) Average velocity of anterograde run is decreased significantly in heterozygous and heteroallelic pol γ mutants while average velocity of retrograde runs is affected; numbers at the base of columns indicate number of mitochondria traced. All error bars represent 95% confidence intervals. * indicates p<0.05 and ** indicates p<0.001 from Student's t-test.