Table 3.

IgG Responses to Human Recombinant ErbB-2 Protein MBS1432470, HER-2 Sequence 1-398, by ELISA

Serum Antibody	Trastuzumab-Negative Control	Individual Patient OD (415 nm) Values to Human Recombinant HER2 by Patient
		1A	1B	1D	2A	4A	4B	4C	4D	4E	4F
OD value, 415 nm	−0.2	0.589	0.786	0.225	0.419	0.23	0.86	0.427	0.695	0.361	0.468

NOTE. Individual patients A through F are in cohort 4. Results of each patient in dose level 4 (ie patients 4A through 4F) and those with a clinical response (ie, patients 1A, 1B, 1D, and 2A) are shown, using a 1:16 dilution of patient sera. The y-axis represents the absorbance after subtracting patient presera (ie, day 1) value.

Abbreviations: IgG, immunoglobulin G; HER-2, human epidermal growth factor receptor 2; ELISA, enzyme-linked immunosorbent assay; OD, optical density.