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. Author manuscript; available in PMC: 2009 Nov 5.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2003 Oct 9;24(1):167–174. doi: 10.1161/01.ATV.0000099881.83261.D4

Figure 1.

Figure 1

Location of genetic markers and SNPs in a 108 kbp interval containing the APOA1/C3/A4/A5 gene cluster. A, Organization of the cluster (not drawn to scale) was determined from genomic (AC007707) and cDNA sequences.11 Genes are denoted by black rectangles, with attached triangles at their 3′ ends. SNPs shown in white on a black background alter the 19th codon (Ser to Trp) of APOA5 (APOA5c.56C>G) and the 40th nucleotide of the 3′ noncoding region of APOC3 (APOC3c.386C>G). The SNP at the APOA5c.−3A>G locus resides within the putative Kozak35 sequence of APOA5. Alternative nomenclature for the APOC3c.386G and APOA1−3,031T alleles include the S2 allele of APOC326 and the X2 allele of APOA1.17 B, Common, APOA5c.56G and APOC3c.386G haplotypes. 1 and 2 represents the major and minor alleles at each locus, respectively.