TABLE 2.
PDT Results for the APOA5c0.56C>G and APOC3c0.386C>G Loci in Familial Combined Hyperlipidaemia
| Trios |
Discordant Siblings |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Transmitted |
Nontransmitted |
Affected |
Unaffected* |
|||||||
| Allele | Trait | %† | n | % | n | %‡ | n | % | n | PDT P Values, Sum/Average |
| APOA5c0.56G | TG | 10.2 | 18 | 8.5 | 15 | 10.6 | 41 | 5.7 | 22 | 0.004/0.010 |
| CHL | 9.9 | 13 | 8.3 | 11 | 11.1 | 37 | 5.1 | 19 | 0.005/0.022 | |
| APOB | 8.3 | 15 | 6.7 | 12 | 13.4 | 45 | 8.0 | 27 | 0.023/0.050 | |
| APOC3c0.386G | TG | 12.6 | 22 | 8.1 | 14 | 14.6 | 56 | 10.1 | 39 | 0.019/0.011 |
| CHL | 13.9 | 18 | 6.9 | 9 | 15.7 | 52 | 10.5 | 39 | 0.010/0.007 | |
| APOB | 11.2 | 20 | 9.6 | 17 | 13.8 | 47 | 9.7 | 33 | 0.088/0.124 | |
n=number of alleles.
Levels <age-sex-specific 90th percentile values.
Allele percentage transmitted to affected offspring calculated from total number of alleles (ie, major plus minor) transmitted to offspring. Conversely, percentage not transmitted to offspring calculated from the total of parental alleles not transmitted to offspring.
Percentage of minor alleles transmitted to affected and unaffected siblings calculated from total number of alleles (ie, major plus minor) in the discordant sibling pair data set.
TG indicates serum triglyceride>age-sex-specific 90th percentile values; CHL, serum cholesterol and triglyceride>age-sex-specific 90th percentile values; APOB, apoB>age-sex-specific 90th percentile values.