. Author manuscript; available in PMC: 2009 Nov 5.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2003 Oct 9;24(1):167–174. doi: 10.1161/01.ATV.0000099881.83261.D4

TABLE 3.

Frequencies of the APOA5^c0.56C^>^G and APOC3^c0.386C^>^G Genotypes in Familial Combined Hyperlipidaemia Probands and Spouses and Serum Triglyceride Levels

		Proband (N = 181)		All Spouses (N = 267)^*		Normolipidemic^† Spouses (N3192)
Locus	Genotype	Frequencies (n)	TG, mg/dL^‡	Frequencies (n)	TG, mg/dL^‡	Frequencies (n)
APOA5^c0.56C≥G	1,1	0.785 (142)	3823149^§	0.8653 (231)	129359	0.870 (167)
	1,2	0.188 (34)	4973335	0.127 (34)	128365	0.125 (24)
	2,2	0.028 (5)	9283572	0.007 (2)	122	0.005 (1)
APOC3^c0.386C≥G	1,1	0.724 (131)	4263266	0.8163 (218)	122354^¶	0.859 (165)
	1,2	0.265 (48)	3983122	0.169 (45)	156375	0.135 (26)
	2,2	0.011 (2)	3413134	0.015 (4)	182339	0.005 (1)

Includes all individuals, no exclusion criteria applied.

^†

Cholesterol and triglyceride levels<age-sex-specific 75th percentile values.

^‡

Mean triglyceride levels±SD.

^§

P<0.004 (ANOVA) for the effect of the APO5^c0.56C^>^G genotype on log triglyceride levels.

^||

P<0.01 for comparison between allele frequencies in probands versus all family spouses.

^¶

P<0.007 (ANOVA) for the effect of the APOC3^c0.386C^>^G genotype on log triglyceride levels.