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Effects of surface charge, size and composition on the actin motility of ActA-modified particles.
| Motility | Chargea | Sizea,b | Composition | ||
|---|---|---|---|---|---|
| Fraction | Speed | ||||
| PEI/DNA NP 3 | − | − | ++ | Small | Polymer |
| PLGA–PEI | − | − | + | Large | Polymer |
| DOPE/DOTAP | − | − | +++ | Large | Lipid |
| DOPC (200 nm Ex) | − | − | − | Small | Lipid |
| PLGA (nano) | + | + | −− | Small | Polymer |
| DOPC (Non Ex) | ++ | + | −−− | Large | Lipid |
| PLGA (micro) | +++ | +++ | −− | Large | Polymer |
After ActA modification.
Small <350 nm; large >350 nm.
