Figure 2.

Core PCP protein distribution in planar polarized tissues in Drosophila and vertebrates. Asymmetric cortical distribution of core PCP components is a highly conserved feature of the PCP pathway. Pk/Vang and Fz/Dsh/Dgo complexes segregate to opposite cortical domains in the fly wing, eye, SOP cell, and vertebrate sensory hair cell. The relative cortical distribution of PCP complexes remains untested in individual mammalian hair follicle precursor cells. Asymmetric cortical PCP complexes have not been reported in vertebrate multiciliated epithelial cells; instead, Dsh and Vang localize to the basal bodies.