Table 1.
Clinical variables of study groups (Mean±S.D.)
| Variable | Untreated group |
Untreated group |
Bupropion group |
Bupropion group |
Bupropion group |
|---|---|---|---|---|---|
| Neutral scan (n=20) | Cig cue scan | Pre-treatment (n=17) | Neutral scan | Cig cue scan | |
| Age | 42.5 (±10.6) | – | 41.3 (±13.3) | – | – |
| % Female | 30 | – | 24 | – | – |
| % Left-handed | 10 | – | 6 | – | – |
| Scan interval (days) | 10.9 (±9.2) | – | 8.1 (±4.5) | – | – |
| Cigarettes/day | 32.6 (±12.4) | – | 27.1 (±8.7) | 3.9 (±5.0)c | 3.4 (±4.6)c |
| Years smoking | 25.4 (±8.9) | – | 22.0 (±12.8) | – | – |
| Urge to smoke | 2.9 (±1.6) | 4.1 (±1.6)a | – | 1.1 (±1.4)c | 1.4 (±1.4)c |
| Exhaled CO (ppm) | 24.1 (±9.1) | 23.1 (±8.9) | 23.0 (±7.9) | 8.3 (±6.6)c | 8.7 (±6.6)c |
| HAM-D | 2.0 (±2.6) | 2.2 (±2.7) | – | 2.5 (±2.8) | 1.9 (±2.4) |
| HAM-A | 2.2 (±2.0) | 2.6 (±2.2) | – | 3.6 (±2.9) | 3.0 (±3.4) |
| S-J (mean per item) | 3.4 (±0.7) | 3.7 (±1.0) | – | 3.0 (±0.9)b | 2.8 (±0.7)b |
CO=carbon monoxide; ppm=parts per million; HAM-D=Hamilton Depression Rating Scale (17-item) (range 0–52); HAM-A=Hamilton Anxiety Rating Scale (range 0–56); S-J=Shiffman–Jarvik Rating Scale mean (±S.D.) per item score.
a
Student’s t-test comparing differences in Urge to Smoke Scale scores between groups from the neutral to the cigarette cue scan, P=0.05.
b
Student’s t-test between groups for corresponding scan, P<0.05.
c
Student’s t-test between groups for corresponding scan, P<0.0005.