Table 2.

Cigarette Dose, Venous Plasma Nicotine Concentration, and Percentage Change in Occupancy of Nicotinic Acetylcholine Receptors in Regions of Interest From Before Smoking to 3.1 Hours After Smoking^a

Dose, Cigarette	Nicotine Level, ng/mL	Without Correction, %				With Correction,%
		Thalamus	Brainstem	Cerebellum	Average	Thalamus	Brainstem	Cerebellum	Average
0.08	0.5 ± 0.1b	17 ± 7	21 ± 9	20 ± 8	19 ± 1	30 ± 6	34 ± 8	34 ± 7	33 ± 1
0.25	1.7 ± 0.1	66 ± 3	66 ± 3	74 ± 3	69 ± 2	72 ± 3	74 ± 3	80 ± 2	75 ± 2
1.00	3.8 ± 0.5	81 ± 2	85 ± 1	85 ± 2	83 ± 1	84 ± 2	90 ± 1	89 ± 2	88 ± 2
2.83	8.8 ± 1.7	98 ± 2	91 ± 2	92 ± 4	93 ± 2	98 ± 2	93 ± 1	93 ± 2	95 ± 2

^aValues are expressed as mean±SE. Data are presented both without and with correction for the imperfect steady state from the bolus-plus-infusion method used herein as described in the “Results” section, paragraph 4.

^bAt 3.1 hours after smoking, the concentration was lower than the detection limit, so values were calculated based on the concentrations measured 10 minutes after smoking (1.2 ± 0.2 ng/mL) and assuming that the half-life for nicotine was t_1/2= 145 minutes.