TABLE 1.
Markers of pulmonary inflammation in control and silica-treated rats.
| Silica dose | BAL Cells | AM Chemiluminescence | ||
|---|---|---|---|---|
| Total | NO-dependent | |||
| (mg silica/100g body weight) | AM (×106/rat) | PMN (×106/rat) | cpm × 105/0.25 × 106 AM/15 min | cpm × 105/0.25 × 106 AM/15 min |
| 0 | 9.69 ± 0.86a | 0.15 ± 0.04a | 15.32 ± 2.98a | 2.43 ± 0.70a |
| 0.1 | 10.19 ± 1.25a | 6.20 ± 1.27b | 103.43 ± 18.72b | 55.34 ± 11.72b |
| 1 | 10.78 ± 1.35a | 18.42 ± 2.70c | 155.15 ± 17.75b | 75.37 ± 11.77b |
| 5 | 10.37 ± 0.94a | 20.13 ± 3.20c | 147.63 ± 23.66b | 57.50 ± 11.57b |
a
Data are expressed as means ± SE (n=7–8).
b
Four experiments, each consisting of two rats/dose, were conducted.
c
Values within the same column with different superscripts are significantly different.