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. Author manuscript; available in PMC: 2010 Sep 30.
Published in final edited form as: J Am Chem Soc. 2009 Sep 30;131(38):13709–13721. doi: 10.1021/ja9039373

Figure 1.

Figure 1

Smac AVPI peptide and the general modification strategy for the design of small-molecule Smac mimetics. Compounds 22 and 23 were designed in our laboratory, whereas compounds 32 and 36 were designed and evaluated by scientists at Genentech.