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. Author manuscript; available in PMC: 2010 Sep 30.
Published in final edited form as: J Am Chem Soc. 2009 Sep 30;131(38):13709–13721. doi: 10.1021/ja9039373

Figure 3.

Figure 3

(A) Crystal structure of XIAP-BIR3 and the AVPI peptide (PDB entry: 1G73) in green. XIAP-BIR3 residues interacting with the AVPI peptide are labeled in black. (B) Binding model of compound 23 and XIAP-BIR3 superimposed with the crystal structure (RMSD=0.81 Å). (C) Binding model of XIAP-BIR3 with compound 22 and (D) with compound 32. The AVPI peptide is superimposed with compounds 22 in (C). The crystal structure of compound 32 is with XIAP-ML-IAP chimera protein.