Table 1.

Chemical Structures of Smac mimetics and their binding affinities to XIAP BIR3 studied in this work.

Compd.	Ref.	Structure	Ki ± SD (µM)	Compd.	Ref.	Structure	Ki ± SD (µM)
1	32		0.29 ± 0.07	17	33		54 ± 7
2	32		4.47 ± 0.65	18	34		0.35 ± 0.005
3	33		13.40 ± 1.6	19	32		0.16 ± 0.02
4	33		2.45 ± 0.7	20	35		0.026 ± 0.0026
5	33		4.41 ± 1.5	21	36		0.02 ± 0.0145
6	33		1.27 ± 0.2	22	37		0.0039 ± 0.0018
7	33		0.22 ± 0.07	23	34		0.067 ± 0.0018
8	33		0.18 ± 0.07	24	37		0.209 ± 0.073
9	33		4.9 ± 2.1	25	37		0.014 ± 0.005
10	33		0.15 ± 0.09	26	36		0.0054 ± 0.003
11	33		0.028 ± 0.020	27	36		0.0084 ± 0.0016
12	33		0.024 ± 0.020	28	38		0.030 ± 0.0044
13	33		1.2 ± 0.4	29	38		0.69 ± 0.2
14	33		68 ± 7	30	38		0.018 ± 0.010
15	33		0.081 ± 0.06	31	33		0.58 ± 0.15
16	33		4.15 ± 1.2