Figure 2. Effects of long-term hyperglucagonaemia on fasting blood glucose (A) and glucose tolerance (B) in glucagon-infused mice.

Values are means ± S.E.M. (n = 8). **P < 0.01 compared with basal (week 0) for fasting blood glucose (in A) or compared with 0 min for the GTT within the same group (in B). ++P < 0.01 compared with glucagon-infused mice at corresponding periods. Ant, [Des-His1-Glu9]glucagon.