Table 1.
Effects of the glucagon receptor antagonist [Des-His1-Glu9]glucagon on long-term hyperglucagonaemia-induced SBP, and metabolic and renal phenotypes in glucagon-infused mice
| Parameter | Control | Glucagon | Glucagon + [Des-His1-Glu9]glucagon |
|---|---|---|---|
| Body weight (g) | 24.2 ± 0.4 | 23.3 ± 0.5 | 21.9 ± 0.6 |
| Water intake (ml/24 h) | 3.9 ± 0.3 | 3.9 ± 0.2 | 3.1 ± 0.4* |
| SBP (mmHg) | 111 ± 3 | 134 ± 5 | 104 ± 4++ |
| Heart rate (beats/min) | 619 ± 18 | 658 ± 16 | 611 ± 25 |
| Heart weight (mg) | 146.9 ± 4.8 | 160.5 ± 6.2* | 140.5 ± 4.3+ |
| Kidney weight (mg) | 117.6 ± 4.4 | 126.2 ± 3.3* | 110.5 ± 3.9+ |
| Urine excretion (ml/24 h) | 1.2 ± 0.1 | 1.6 ± 0.2* | 1.1 ± 0.1+ |
| Haematocrit (%) | 40.2 ± 1.0 | 44.1 ± 1.0* | 43.2 ± 1.0* |
| Serum glucagon (pg/ml) | 240.9 ± 37.6 | 445 ± 45.6** | 882.5 ± 50.5**++ |
| Serum insulin (pg/ml) | 303 ± 63.1 | 249.9 ± 50.8 | 454 ± 71.3+ |
*
P < 0.05 or
**
P < 0.01 compared with control mice;
+
P < 0.05 and
++
P < 0.01 compared with glucagon-infused mice.