Table 2.

Effects of long-term administration of the glucagon receptor antagonist [Des-His¹-Glu⁹]glucagon alone for 4 weeks on SBP, and metabolic and glucose tolerance in mice

Parameter	Basal	Week 1	Week 2	Week 3	Week 4
Body weight (g)	21.6 ± 0.8	21.8 ± 0.5	22.9 ± 0.4	23.8 ± 0.6	24.1 ± 0.4
SBP (mmHg)	116 ± 3	115 ± 5	115 ± 3	113 ± 4	115 ± 3
Water intake (ml/24 h)	4.0 ± 0.4	4.0 ± 0.2	3.6 ± 0.2	3.4 ± 0.2	3.4 ± 0.2
Urine excretion (ml/24 h)	1.01 ± 0.14	0.38 ± 0.15**	0.73 ± 0.12*	0.62 ± 0.11**	0.57 ± 0.21**
Heart weight (mg)	n/a	n/a	n/a	n/a	105.4 ± 2.5
Kidney weight (mg)	n/a	n/a	n/a	n/a	116.3 ± 2.1
Fasting blood glucose (mg/dl)	85.3 ± 8.8	95.3 ± 4.2	84.3 ± 1.7	80.7 ± 3.6	73.7 ± 2.2*
Postprandial blood glucose (mg/dl)	145.6 ± 4.8	n/a	130.5 ± 3.9*	n/a	142 ± 7.4
GTT (mg/dl)
30 min	263.5 ± 9.4	n/a	256.7 ± 8.9	n/a	252.7 ± 16.1
60 min	194.8 ± 10.3	n/a	154.7 ± 4.8*	n/a	159.3 ± 8.4*
90 min	145.3 ± 5.6	n/a	128.8 ± 9.6	n/a	133.5 ± 8.4
120 min	136.7 ± 6.5	n/a	117.5 ± 6.8*	n/a	120.7 ± 7.8
Serum glucagon (pg/ml)	n/a	n/a	n/a	n/a	407.3 ± 92.3
Serum insulin (pg/ml)	n/a	n/a	n/a	n/a	949 ± 133

n/a, not measured at this time-point.

^*P < 0.05 and

^**P < 0.01 compared with basal.