Table 3.

Effects of long-term administration of a high glucose load alone (2 % in drinking water) for 4 weeks on SBP, and metabolic and glucose tolerance in mice

Parameter	Basal	Week 1	Week 2	Week 3	Week 4
Body weight (g)	22.7 ± 0.6	24.5 ± 0.7	24.8 ± 0.7	24.9 ± 0.7	25.2 ± 0.7
SBP (mmHg)	119 ± 3	120 ± 4	118 ± 3	117 ± 3	117 ± 3
Water intake (ml/24 h)	4.7 ± 0.2	5.7 ± 0.4*	5.3 ± 0.2	5.6 ± 0.3*	4.5 ± 0.3
Urine excretion (ml/24 h)	1.1 ± 0.2	1.7 ± 0.4*	2.1 ± 0.4*	2.1 ± 0.2*	1.3 ± 0.2
Heart weight (mg)	n/a	n/a	n/a	n/a	111.1 ± 3.2
Kidney weight (mg)	n/a	n/a	n/a	n/a	116.8 ± 5.5
Fasting blood glucose (mg/dl)	81.4 ± 5.2	88.2 ± 6.3	78.5 ± 5.6	78.4 ± 2.7	75.9 ± 4.3
Postprandial blood glucose (mg/dl)	154.6 ± 11.5	n/a	163.4 ± 5.9	n/a	164.2 ± 5.7
GTT (mg/dl)
30 min	237 ± 7.9	n/a	230.0 ± 17	n/a	258.3 ± 17.1
60 min	178.4 ± 6.8	n/a	171.7 ± 11	n/a	182.5 ± 14.7
90 min	147.6 ± 2.2	n/a	153.7 ± 5.2	n/a	148.0 ± 11.8
120 min	132.1 ± 4.6	n/a	138.6 ± 3.7	n/a	133.4 ± 8.9
Serum glucagon (pg/ml)	n/a	n/a	n/a	n/a	208.8 ± 47.6
Serum insulin (pg/ml)	n/a	n/a	n/a	n/a	1335 ± 103

n/a, not measured at this time-point.

^*P < 0.05 compared with basal.