Table I. The main biological functions, networks, and diseases extracted from the rank product list and the associated protein IDs as assessed with Ingenuity Pathways Analysis.
Proteins shown in italics were added to the networks by the Ingenuity Pathway Knowledge Base, which was used as a reference data set. MAPK, mitogen-activated protein kinase; ERK, extracellular signal-regulated kinase; PI3K, phosphatidylinositol 3-kinase; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; Jnk, c-Jun NH2-terminal kinase; PLC, phospholipase C.
Top functions | Associated molecules | Score | Focus molecules |
---|---|---|---|
Networks | |||
Cell-to-cell signaling and interaction, hematological disease, hematological system development and function | Akt, ALB, ANXA1, ANXA2, ANXA5, ANXA6, ATP1A2, calmodulin, calpain, CALR, CANX, CD9, CKAP4, COX2, CYCS (includes EG:54205), EGFR, ERK, F-actin, GAP43, GAPDH (includes EG:2597), HSPD1, interferon α, Jnk, Mapk, MARCKS (includes EG:4082), MARCKSL1, MHC class I, NFκB, p38 MAPK, P4HB, PDIA3, PI3K, Pkc(s), PLC, Ras | 47 | 20 |
Amino acid metabolism, small molecule biochemistry, lipid metabolism | Acetyl-CoA C-acetyltransferase, ASGR1, ATF4, CPT2, CS, CYC1, cytochrome bc1, FH, GANAB, GOLIM4, GOT2, HADHA, HADHB, HLA-F, HNF4A, HSPA9, IFNB1, KARS, KRT2, LETM1, MAGEA1 (includes EG:4100), MDH2, NFKB1, PELO, PYCR1, SGK1, SLC25A6, SMAD3, SSBP1, TIMM23, TIMM50, UQCRB, UQCRFS1, UQCRFSL1, UQCRH | 32 | 15 |
Energy production, nucleic acid metabolism, small molecule biochemistry | Adenosine-tetraphosphatase, AGT, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5L, ATP6V0C, β-estradiol, CR1, CRABP2, CRIP2, cyclic GMP, DECR1, FDFT1, H+-transporting two-sector ATPase, hemin, HLA-DRB1, IDH2, IFNG, MARCKSL1, MSR1, NFYA, PDIA3, PHLDA3, PKM2, PLA2G1B, RRBP1, SDHA, SLC1A3, TAP2, TOMM22 | 27 | 13 |
Top functions | Associated molecules | p value | No. of molecules |
---|---|---|---|
Diseases and disorders | |||
Neurological disease | ANXA2, ATP1A2, ATP5A1, ATP5L, CALR, CANX, COX2, CYCS (includes EG:54205), EGFR, GAP43, GAPDH (includes EG:2597), HADHA, HADHB, HSPD1, MARCKS (includes EG:4082), MARCKSL1, PDIA3, PKM2, SDHA, SLC1A3, SLC25A6, SSBP1, UQCRB | 2.43e−07–4.87e−02 | 24 |
Cancer | ALB, ANXA1, ANXA2, PKM2, CD9, EGFR, CALR, COX2, ANXA5, ATP1A2, CANX, P4HB, GAP43, SLC25A6, CYCS (includes EG:54205), GAPDH (includes EG:2597), HSPD1, PDIA3, DECR1, SLC1A3 | 5.32e−06–4.98e−02 | 20 |
Molecular and cellular functions | |||
Energy production | ATP1A2, ATP5A1, ATP5F1, ATP5L, MDH2, HSPD1, CYCS (includes EG:54205), SDHA, UQCRFS1 | 2.32e−06–2.64E-02 | 9 |
Nucleic acid metabolism | ATP1A2, ATP5A1, ATP5F1, ATP5L, HADHA, HSPD1, EGFR, GAPDH (includes EG:2597), CYCS (includes EG:54205) | 2.32e−02–2.47e−02 | 9 |
Small molecule biochemistry | HSPD1, CALR, P4HB, MDH2, CYCS (includes EG:54205), ATP1A2, MARCKS (includes EG:4082), GANAB, HADHB, SLC1A3, EGFR, ANXA2, ANXA5, PDIA3, CD9, ATP5A1, HADHA, ATP5F1, ATP5L, ALB, PYCR1, GAPDH (includes EG:2597), CPT2, ANXA1 | 2.32e−06–4.53e−02 | 24 |
Cell-to-cell signaling and interaction | HSPD1, CALR, EGFR, ANXA2, ANXA5, CKAP4, KRT2, PDIA3, MARCKSL1, GAP43, CD9, ALB, ANXA1 | 1.24e−05–4.98e−02 | 13 |
Molecular transport | CALR, ATP1A2, MARCKS (includes EG:4082), SLC1A3, UQCRFS1, CCHCR1, SDHA, PDIA3, CD9, HADHA, ALB, ANXA1, HSPA9, CPT2, GAPDH (includes EG:2597) | 2.77e−05–4.53e−02 | 15 |
Top functions | Associated molecules | p value | Ratio |
---|---|---|---|
Canonical pathways | |||
Oxidative phosphorylation | ATP5A1, ATP5F1, ATP5L, COX2, SDHA, UQCRB, UQCRFS1 | 5.62e−07 | 7:157 |
Mitochondrial dysfunction | ATP5A1, COX2, CYCS (includes EG:54205), SDHA, UQCRB, UQCRFS1 | 1.52e−05 | 6:170 |