Figure 3.

Accumulation of Erufosine in brain tissue after repeated intraperitoneal drug injections. Mice were treated every 48 hours with intraperitoneal injections of Erufosine at the indicated concentrations for one, two or three weeks. At the end of the treatment period mice were killed, organs removed and organ concentrations of Erufosine were determined by LC-MS/MS analysis. A. Brain and serum concentrations of Erufosine after treatment with 20 mg/kg body weight of Erufosine for 7 d and 21 d, respectively. Data show means ± SD (n = 3-6). B. Mean organ concentrations of Erufosine after treatment with 5, 10, 20 or 40 mg/kg body weight for 14 or 21 days were divided by the mean organ concentrations after the respective treatment for 7 days. Data show means ± SEM of the resulting quotients from all 4 dose groups (n = 12-24).