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. 2009 Oct 20;9:53. doi: 10.1186/1471-213X-9-53

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Copyright © 2009 Wu et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Genetic interactions of ras with genes involved in growth and survival. (A) ras^KPmutant eye is small and rough. (B) GMR-p35 only partly suppresses the ras^KP-induced cell death. (C) In the hid null background, ras^KP-induced cell death is also partially suppressed. Ectopic expression of PI3K (D), Akt (E) and buffy (F) have no effect on the ras^KPeye phenotype. Genotypes: (A)GMR-Gal4/CyO; ras^KP/ras^KP, (B)GMR-p35/CyO; ras^KP/ras^KP, (C)Df(3L)H99, ras^KP/hid⁰⁵⁰¹⁴ras^KP, (D)GMR-Gal4/UAS-p110; ras^KP/ras^KP, (E)GMR-Gal4/UAS-AKT; ras^KP/ras^KP, (F)GMR-Gal4/UAS-buffy; ras^KP/ras^KP.