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. Author manuscript; available in PMC: 2009 Nov 5.
Published in final edited form as: Arch Biochem Biophys. 2007 May 11;464(2):197–206. doi: 10.1016/j.abb.2007.04.028

Table 2.

Binding affinities of wild-type P450 2A6 and mutants for indole.

P450 2A6 construct Kd (μM)1 Δε max1 (mM-1cm-1)
Wild-type P450 2A6 81.2 ± 13.7 54.8 ± 0.6
P450 2A6 N297Q 14.4 ± 1.1 58.3 ± 2.8
P450 2A6 L240C/N297Q 22.8 ± 3.6 59.0 ± 5.4
P450 2A6 N297Q/I300V 17.7 ± 1.8 52.7 ± 2.3
1

Mean and standard errors are shown for at least three titrations for each enzyme