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. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: Angew Chem Int Ed Engl. 2009;48(23):4146–4149. doi: 10.1002/anie.200900111

Figure 5.

Figure 5

Survival and biodistribution data of doxorubicin-loaded dSML liposomes on BALB/C mice bearing C-26 tumor. A single dose of 15 mg/kg liposomal doxorubicin or 10 mg/kg for free doxorubicin was administered i.v. on day 8 after the tumor inoculation. Panel (A): survival curves. 1-Dox: dSML1/DSPC/DSPE-PEG2000/α-tocopherol (33.0/61.8/5.0/0.2); 2a-Dox-F1: dSML2a/DSPC/DSPE-PEG2000/α-tocopherol (33.0/61.8/5.0/0.2); 2a-Dox-F2: dSML2a/DSPE-PEG2000/α-tocopherol (94.8/5.0/0.2) Log-rank analysis of the paired survival data: p = 0.0019 for 1-Dox, 2a-Dox-F1, 2a-Dox-F2, and Doxil vs PBS; P = 0.0018 for 1-Dox, 2a-Dox-F1, 2a-Dox-F2, and Doxil vs Free Dox. No significant difference between 1-Dox, 2a-Dox-F1, 2a-Dox-F2, and Doxil. Panel (B): liposomal doxorubicin biodistribution 48 hours after i.v. injection at 15 mg/kg.