Table 2.
Blood pressure and HR response to exercise in R92WTNNT2 and MYH7 mutation carriers and noncarrier controls
| MYH7 | R92WTNNT2 | Controls | P | |
|---|---|---|---|---|
| Total exercise time, seconds | 528 (96–1104) | 379 (266–937) | 467 (171–1319) | .339 |
| MET, kcal/min | 6.5 (2.3–12.2) | 6.5 (3.9–14.7) | 6.2 (2.9–12.1) | .660 |
| % HR achieved | 96 (74–104) | 89 (56–104) | 94 (75–108) | .417 |
| %CR | 88.0 (32.3–141.2) | 83.7 (24.8–143.1) | 89.4 (54.1–118.5) | .487 |
| HRpeak, bpm | 171 (129–203) | 169 (98–211) | 170 (123–197) | .449 |
| ΔHR, bpm | 92.0 (10–140) | 92.0 (28–136) | 90.5 (44–137) | .499 |
| Abnormal blood pressure response, any (%) | 12 (24) | 14 (48) | 16 (24) | .021 |
| Flat (%) | 10 (20) | 14 (48) | 11 (16) | .018 |
| Hypotensive (%) | 2 (4) | 0 (0) | 5 (8) | .357 |
| SBPpeak, mmHg | 160 (120–230) | 140 (100–190) | 160 (110–220) | .064 |
| ΔSBP, mmHg | 35 (0–100) | 30 (10–60) | 40 (5–100) | .020 |
| DBPpeak, mmHg | 90 (70–120) | 90 (50–100) | 90 (60–120) | .589 |
| ΔDBP, mmHg | 10 (−20–40) | 10 (−10–30) | 10 (−20–40) | .732 |
Note: Values are given as median (range) for continuous variables and as numbers (percentage) for categorical variables. P-values reflect differences between groups for quantile normalized data, adjusted for age, sex, resting mean arterial pressure, and resting HR. Δ = change in parameter between resting and peak exercise; peak = parameter at peak exercise; % HR achieved = % of predicted maximal HR achieved by peak exercise.