TABLE 1.
RECIPIENT, DONOR, AND PROCEDURE CHARACTERISTICS AT THE TIME OF TRANSPLANTATION
| Underweight | Normal Weight | Overweight | Obese | |
|---|---|---|---|---|
| No. | 862 | 2,864 | 1,644 | 608 |
| Recipient characteristics | ||||
| Age, years | 42 (27–56) | 54 (45–60) | 57 (51–61) | 56 (50–60) |
| Male | 353/862 (41%) | 1,489/2,864 (52%) | 1,012/1,644 (62%) | 338/608 (56%) |
| Height, cm | 168 (160–173) | 169 (163–177) | 173 (163–178) | 170 (160–178) |
| Lung allocation score, au | 34 (33–36) | 33 (32–35) | 32 (31–35) | 32 (31–(35) |
| Waiting list urgency score, days | 342 (332–350) | 349 (338–355) | 350 (330–356) | 350 (328–358) |
| Posttransplant survival score, days | 330 (328–331) | 328 (327–329) | 327 (309–328) | 318 (303–228) |
| Diagnosis | ||||
| Cystic fibrosis | 410/862 (48%) | 519/2,864 (18%) | 34/1,644 (2%) | 3/608 (<1%) |
| COPD | 411/862 (48%) | 1,976/2,864 (69%) | 1,078/1,644 (66%) | 301/608 (50%) |
| DPLD | 41/862 (5%) | 369/2,864 (13%) | 532/1,644 (32%) | 304/608 (50%) |
| Hospitalized | 86/854 (10%) | 137/2,844 (5%) | 43/1,640 (3%) | 16/605 (3%) |
| Corticosteroid use | 326/799 (41%) | 1312/2,623 (50%) | 846/1,517 (56%) | 333/560 (59%) |
| Diabetes | 94/819 (11%) | 184/2,726 (7%) | 89/1,587 (6%) | 71/588 (12%) |
| Hypertension | 51/815 (6%) | 315/2,709 (12%) | 255/1,574 (16%) | 126/584 (22%) |
| Ever smoker | 340/793 (43%) | 1,723/2,651 (65%) | 1,134/1,554 (73%) | 414/575 (72%) |
| Year of transplantation | ||||
| 1995–1999 | 487/862 (56%) | 1,410/2,864 (49%) | 738/1,644 (45%) | 265/608 (44%) |
| 2000–2003 | 375/862 (44%) | 1,454/2,864 (51%) | 906/1,644 (55%) | 343/608 (56%) |
| Cytomegalovirus mismatch (D+/R−) | 97/389 (25%) | 330/1,504 (22%) | 163/904 (18%) | 63/334 (19%) |
| >3 human leukocyte antigen mismatches | 585/707 (83%) | 1,929/2,340 (82%) | 1,121/1,350 (83%) | 410/480 (85%) |
| Donor characteristics | ||||
| Age, years | 27 (19–42) | 29 (20–43) | 29 (20–43) | 29 (20–43) |
| Male | 471/862 (55%) | 1,799/2,864 (63%) | 1,108/1,644 (68%) | 394/608 (65%) |
| Height, cm | 170 (165–178) | 173 (168–180) | 175 (168–183) | 175 (168–183) |
| Body mass index, kg/m2 | 23 (21–26) | 24 (21–26) | 24 (21–27) | 24 (22–27) |
| Smoking >20 pack-years | 243/847 (29%) | 815/2,843 (29%) | 473/1,620 (29%) | 172/594 (29%) |
| Bronchopulmonary infection | 134/862 (16%) | 426/2,864 (15%) | 284/1,644 (17%) | 111/608 (18%) |
| Diabetes | 22/855 (3%) | 85/2,848 (3%) | 50/1,637 (3%) | 18/602 (3%) |
| Cause of death | ||||
| Head trauma | 488/862 (57%) | 1,637/2,864 (57%) | 928/1,644 (56%) | 348 (57%) |
| Cerebrovascular | 303/862 (35%) | 1,055/2,864 (35%) | 588/1,644 (36%) | 208/608 (34%) |
| Anoxic brain injury | 43/862 (5%) | 142/2,864 (5%) | 81/1,644 (5%) | 30/608 (5%) |
| CNS tumor | 11/862 (1%) | 35/2,864 (1%) | 17/1,644 (1%) | 7,608 (1%) |
| Missing | 17/862 (2%) | 45/2,864 (2%) | 30/1,644 (2%) | 15/608 (2%) |
| Procedure characteristics | ||||
| Bilateral lung transplantation | 516/862 (60%) | 1,189/2,864 (42%) | 1,188/1,644 (26%) | 462/608 (24%) |
| Ischemic time, hours | 4.6 (3.5–6) | 4.3 (3.3–5.3) | 4.2 (3.3–5.3) | 4.0 (3.1–5.1) |
| n = 756 |
n = 2,463 |
n = 1,408 |
n = 527 |
|
Definition of abbreviations: au = arbitrary units; CNS = central nervous system; COPD = chronic obstructive pulmonary disease; DPLD = diffuse parenchymal lung disease.
Data represent median (interquartile range) and frequency/total (%). Percentages may not add to 100% because of rounding. Continuous variables all had complete data (n = 5,978) except for ischemic time as noted.