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Adenine excision catalyzed by MutY. (A) A close-up view of the substrate adenosine interacting with catalytic residues in the FLRC. The same color scheme as in Fig. 4A. Important hydrogen bonding contacts are illustrated by dotted lines. The nucleophilic water candidate is in red sphere. Distance between C1′ of the substrate base and the water molecule is denoted by a double arrow. (B) A proposed glycolytic mechanism based on the structural information of the FLRC.
