Fig. 2.

Effect of AdCA5 therapy on the recovery of diabetic mice after ischemia. AdLacZ or AdCA5 was administered immediately after femoral artery ligation. (A) Representative serial LDPI is shown. (B–D) The ratio of perfusion in nonischemic:ischemic limb was determined (B), and tissue necrosis (C) and ambulatory impairment (D) were scored at each time point. Mean ± SEM values are shown (n = 7). Differences between groups were assessed by two-way ANOVA with Bonferroni correction (brackets at right); ***, P < 0.001 at individual time point.