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. 2009 Nov;175(5):1962–1974. doi: 10.2353/ajpath.2009.090463

Figure 3.

Figure 3

Effect of hypoxia-ischemia on LAMP1 expression and distribution. A–C: Immunohistochemistry after hypoxia-ischemia shows an increase in the LAMP1-positive dots at 6 and 24 hours in the cortex (A) in the border of the lesion (left side of the dotted line) but also in some cells inside the lesion (right side of the dotted line) and CA3 (B). High magnifications of two or more representative neurons are shown for the cortex and CA3, illustrating the substantial increase in the size of LAMP1-positive vesicles from 6 hours after hypoxia-ischemia. C: No change is detectable in CA1. D and E: Confocal microscopy reveals that the increase in LAMP1 occurs in neurons as shown by double immunolabeling for microtubule-associated protein 2 (red) and LAMP1 (green) at 24 hours in cortex (D) and CA3 (E). Scale bars: 10 μm.