Figure 6. Effect of NRP1 Function Blocking Antibodies on Differentiation of Stem Cells to Endothelial Cells.
Panel A–C: Photomicrographs of representative photomicrographs of murine stem cells differentiated to endothelial cells for seven days in the presence of mouse IgG (Panel A), NRP1A Ab (Panel B), NRP1B Ab (Panel C). Results are representative of three independent experiments. Scale bar=20 microns.
Panel D: Summary of three independent experiments, means ± SEM are shown. Significant differences in a one-way ANOVA with Holm-Sidak post-hoc test for VE-Cadherin (*) and CD31 (**) at p>0.001.