TABLE 1.
Collection of biopsies for monitoring the effect of belinostat treatment (Experiment 3)
| Large tumors (1500–1800 mg) |
|||
|---|---|---|---|
| A2780ID | Pretreatment biopsy | PXD101 exposure(h) biopsy | Whole tumor(h) |
| 235 | X | 1 | 3 |
| 234 | X | 1 | 3 |
| 226 | X | 2 | 3 |
| 365 | X | 2 | 3 |
| 232 | X | 3 | 3 |
| 233 | X | 6 | 6 |
| 553 | X | 6 | 6 |
| Small tumors (300–400 mg) |
|||
| A2780ID | Pretreatment biopsy | PXD101 exposure(h) biopsy | Whole tumor(h) |
| 227 | 1 | 3 | |
| 238 | 1 | 3 | |
| 237 | 2 | 3 | |
| 231 | 2 | 3 | |
| 225 | 3 | 3 | |
| 236 | 3 | 3 | |
| 228 | 1 | 6 | |
| 230 | 6 | 6 | |
| 552 | 24 | ||
Seven mice with large A2780 tumors and nine mice with small A2780 tumors were included in the study. The table shows time points for collection of biopsies and removal of whole tumors. Pretreatment biopsies were collected only from mice with large tumors.